Mikado Ryōko/Relationships

Rito Yuuki
Mikado works as the doctor at Rito's school. Rito and the others have a good and trusting friendship with her, and occasionally comes by her office at school to socialize or talk about important matters, such as Golden Darkness, Tearju, and the organization they were associated with, which Mikado is able to investigate through her former black market connections.

Mikado is quite fond of Rito and finds his childlike innocence amusing. She can be quite mischievous with him, and likes to have fun with his shyness around women, such as asking him to take off Yami's clothes so Mikado can treat her sickness, making him rub lotion on her at the beach and instructing Lala to add aphrodisiac to her Valentine chocolate for Rito. She particularly finds his female counterpart Riko Yuusaki interesting and cute and would like to examine her body (though unclear if she was joking).

Oshizu Murasame
Mikado built the artificial body that Oshizu inhabits so that she may live like a normal physical girl. Oshizu now lives with Mikado and works at her clinic as her assistant, though she can be quite clumsy sometimes. Oshizu is quite obedient to Mikado, like when she was told by her to use her powers to force Rito to rub lotion on Mikado's back.

Tearju Lunatique
Tearju and Mikado have been friends since they were in school together. They went their separate ways some time before Tearju was recruited into the suspicious organization where she would eventually create Eve (Golden Darkness).

In To Love-Ru Darkness, Mikado eventually reunited with Tearju to tell her how Eve is doing on Earth. It was because of Mikado that Tearju came to Earth and became a substitute teacher for Rito's class, and soon later Yami, Mea, Nana and Momo's homeroom teacher.